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Observational studies are limited in their ability to establish causality by the influence of bias and confounding variables. Confounding variables can also threaten the validity of observational studies, and Alli diet pills side effects liver these variables are unknown, unmeasured or inaccurately measured, statistical adjustment cannot adequately mitigate their effects.

Because these limitations leave the door https://where.dietasfaciles.site/pagina12179-nutrientes-esenciales-para-la-perdida-de-peso-repentina.php for alternative aetiologies of AKI, causality is difficult to establish outside the setting of randomized trials.

Alli diet pills side effects liver, trials designed to establish efficacy are not often powered to detect rare outcomes such as AKI [ Alli diet pills side effects liver et al. Furthermore, patients with pre-existing CKD, who would likely be at the highest risk for developing AKI, are often excluded from randomized trials [ Coca et al.

The existing trials of orlistat do not provide information on the risk of AKI and given perdiendo peso flagging market share, we are unlikely to see future large-scale trials Alli diet pills side effects liver this drug.

Establishing unequivocal causality in the setting of adverse drug reactions is very difficult. Without evidence from randomized trials or multiple observational studies, we cannot confidently label orlistat a cause of AKI. However, we believe there is sufficient evidence to consider exposure to orlistat a potential cause of AKI.

In patients with otherwise unexplained AKI, discontinuation of orlistat would be a reasonable course of action and in patients at risk of AKI, such as those with multiple comorbidities or pre-existing CKD, orlistat should be prescribed with caution and close observation.

Authors acknowledge Brogan Inc. The opinions, results and conclusions are those of the authors and are independent from the funding sources.

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The authors declare that there are no conflicts of interest. National Center for Biotechnology InformationU. Ther Adv Drug Saf. Michael M. BeyeaAmit X. Gargand Matthew A.

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